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The Systolic Hypertension in Europe (Syst-Eur), a multicenter randomized controlled trial (RCT) conducted by the European Working Party on High Blood Pressure in the Elderly (EWPHE), showed a 50% decrease of dementia incidence during a 2-year period in patients using long-acting calcium-channel blocker nitrendipine 124

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when compared to control animals (Fig

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The company did not share a specific regimen for dosing in the trials